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Systemic Exertion Intolerance Disease: Causes, Symptoms, and Treatments


Systemic exertion intolerance disease (SEID) or chronic fatigue syndrome is a complicated disorder characterized by extreme fatigue that cannot be explained by an underlying medical condition. The fatigue could get worse with physical or mental activity, but does not improve with rest.
SEID most commonly affects people in their 40s and 50s.

- Requires a medical diagnosis
- Incurable
- Symptomatic diagnosis
- Causes are mostly unknown
- Treatment focused on symptom relief
- Diagnostic method is based on symptoms
- Women more likely to get diagnosed
- Chronic: can last for years or lifelong
- Lab tests and imaging often required

This condition is also called as Myalgic Encephalomyelitis (ME) and it limits the person’s ability to carry out ordinary routine activities. Cognitive behavioral therapy (CBT) and gradual increase in activity is suitable in many cases.


1. Viral infections
2. Immune system problems
3. Hormonal imbalance
People may experience:
1. Fatigue
2. Sore throat
3. Loss of memory or concentration
4. Headaches
5. Unexplained muscle or joint pain
6. Unrefreshing sleep


Self-care: Cognitive training and graded exercises are helpful.
Medications: Antidepressants are helpful to improve sleep and relieve pain on doctors prescription.
Specialists: Consult a doctor for immediate concerns. At mfine, we provide a comprehensive treatment plan for optimum health.

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