Certain antibodies that target red blood cells are found using Coombs testing. The immune system produces antibodies, which are proteins. Antibodies normally bind to foreign things, such as bacteria and viruses, and kill them. A Direct Coombs Test, also known as a DAT, can help you figure out why you’re not feeling well or have symptoms that point to a problem with your blood.
If the donor’s blood isn’t a good match, you can feel unwell following a blood transfusion. Even though those other blood cells are supposed to aid, your body may perceive them as alien and produce antibodies to get rid of them. Antibodies kill your own red blood cells faster than your body can produce them, resulting in autoimmune hemolytic anaemia. You can obtain it as a result of:
- Diseases like leukaemia and lupus
- Infections such as mononucleosis
- Medicines, including penicillin