Your blood will be prepared in the lab for osmotic fragility testing, and your red blood cells will be added to solutions with various salt concentrations. Normal blood cells may withstand low salt solutions better than spherocytosis or thalassemia blood cells, which are more fragile.
You most likely have inherited spherocytosis or thalassemia if your cells are frail. Hemolytic anaemia can be caused by one of these hereditary disorders. This type of anaemia develops when your red blood cells are damaged too quickly.
- Thalassemia is a blood disorder that is passed down the generations. It occurs when DNA within cells is mutated.
- Hereditary spherocytosis (HS), is a condition in which red blood cells’ shells, or membranes, are fragile. The red blood cells become smaller as they move through the spleen. As a result, their lifespan is much shorter than that of normal cells.
- Anaemia is a condition in which there aren’t enough red blood cells to carry enough oxygen to your body.
If your osmotic fragility test is positive, the next step is to confirm the results and test whether you are actively anaemic.
Disclaimer: Please consult with your doctor for interpreting the test reports