The amount of calprotectin present in the stool is measured by this test.
Calprotectin is a protein that is produced and released by White Blood Cells (WBCs) called Neutrophils and Monocytes present in our blood. Whenever a tissue or part of our body is under attack by an infection, our immune system tries to defend it by sending Neutrophils through the blood.
These neutrophils act by releasing certain substances, important among them being calprotectin, helping to fight and bring down inflammation.
- Long-standing infection like in Chronic inflammatory bowel disease, these calprotectin levels may rise substantially.
- Sometimes the levels of calprotectin may be low in non-inflammatory conditions of the intestines like IBS.
Thus, calprotectin helps control the infection and is a useful indicator of your bowel or intestinal health.
When there is inflammation or one that does not resolve, it may cause the calprotectin levels to rise substantially over a period of time, which is known as chronic inflammation.
Research says that the sensitivity of a Fecal Calprotectin Test has improved over the years and thus has proved beneficial for Gastroenterologists around the world in managing intestinal conditions.