Thyroxine Binding Globulin

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What is Thyroxine Binding Globulin?

The globulin necessary for binding the thyroid hormones. It is produced by the liver and is a circulating protein. The Thyroxine Binding Globulin (TBG) is present in a really low concentration but still has the power to carry the T3 and T4 cells to the blood plasma. The reference range for TBG is 1.1-2.1 mg/dL. The TBG level may increase or decrease depending upon your lifestyle, the kind of initial medications you had and also your diet. The change in the TBG level can be easily detected through a blood test which also further helps in detecting hypothyroidism or hyperthyroidism in the patient.

Why is it suggested?

 The TBG plays a significant role in having the highest affinity to T3 and T4. Any changes in the TBG level can also lead to alterations in concentration of T3 and T4 in the blood thus leading to confusion and can cause a dysfunction of the thyroid gland as well. Excess level of TBG can indicate hyperthyroidism whereas a lower concentration can specify hypothyroidism. Whenever a person suffers from symptoms like extreme weakness, excessive weight gain, puffy skin, weight changes, irregular menstruation, sensitivity to light, hair loss etc., then the person should consult a doctor and go for a blood test so that if any changes in the TBG level have occurred then it can be detected.

How is it performed?

  • The test is examined through a regular blood test.
  • A blood sample is taken from a vein.
  • The blood sample is sent to the lab for further analysis.
  • After analysing the blood sample, in a few days the test reports are prepared.
  • The reports are received by the patients and then sent to the doctors for suggesting the required solution for treatment.



It is a transport protein that is responsible for carrying thyroid hormones in the bloodstream. Serum TBG can help in the diagnosis of this change. It accounts for 70-75% of the plasma protein.


  1. Follow the guidelines provided for the steps that need to be adopted before a normal blood test is occurred.
  2. Inform the health practitioner about any previous medication and also any other medical history that you had in the past.



Usually there are no risks involved as it is a normal blood test. Minor inflammation in the area where the needle was pierced might occur but apart from this, usually there are no major risks involved.

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