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Synaptophysin

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What is Synaptophysin?35

Synaptophysin is a protein found in neuroendocrine cells. It is used as marker for detecting neuroendocrine tumours in the small intestine, rectum, pancreas, stomach, oesophagus, lungs and appendix.

Why is Synaptophysin test in suggested?2

The test is ordered when the doctor suspects a person has neuroendocrine tumour due to the following symptoms:

  • Diarrhoea.
  • Nausea or vomiting.
  • Wheezing, coughing, difficult breathing.
  • Rapid heart rate.
  • Abdominal pain.
  • Bleeding in the stool or rectum.
  • Low blood pressure.

The test is also used to evaluate treatment effectiveness and monitor for tumour recurrence.

How is Synaptophysin test performed?1

Synaptophysin test is a blood test. The nurse/lab technician rinses the skin with an alcohol pad, inserts a needle into a vein on the rinsed skin, draws the blood and stores it in a small vial. You may feel a slight pinch. The nurse will place a dressing strip on the skin immediately after the process.

The blood sample is sent to the laboratory for diagnosis.

What are the parameters measured in Synaptophysin test?2

High levels of Synaptophysin in a person with the symptoms may indicate tumour, but does not determine the exact source. Further tests need to be done to determine the location of tumour.

Low levels or normal levels of the protein indicate there is no tumour.

Preparation before performing Synaptophysin test21

There is no fasting required before the test, unless stated by the doctor.

Your doctor might ask you to stop taking any medicines before the test as they may interfere with the test result. He/she will also ask about your lifestyle, family history etc. Consult your doctor before taking any medicines before the test.

Post-care after Synaptophysin test1

Do not remove the dressing strip before 30 mins-1 hour. Avoid any strenuous activity throughout the day. If bleeding occurs, apply pressure with your fingers at the needle site. Avoid wearing tight clothes on your arms.

Sample types in Synaptophysin test25

Blood sample.

 Side effects/risks of Synaptophysin test1

Side effects of the blood test might include:

  • Bleeding.
  • Discomfort.
  • Swelling.
  • Slight bruising or throbbing on the needle site.

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