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Methyl Malonic Acid Quantitative

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Overview Brief

Methyl malonic acid quantitative test is done to measure the amount of methylmalonic acid (MMA) in the body.

What is methyl malonic acid quantitative test?

Methyl malonic acid quantitative test helps in the detection of Vitamin B12 deficiency and also helps in the diagnosis of methylmalonic acidemia (a rare disorder).

Methyl malonic acid quantitative is a substance that reacts with Vitamin B12 and helps in identifying B-12 deficiencies.

Methyl malonic acid quantitative test is more sensitive than the Vitamin B-12 test.

Why is methyl malonic acid quantitative test suggested?

Your healthcare provider might suggest you methyl malonic acid quantitative test if you have the symptoms of B12 deficiency:

  • Diarrhea
  • Breathing problems; rapid heart rate
  • Appetite loss
  • Dizziness
  • Headache
  • Pale skin
  • Burning in feet, arms, legs
  • Paranoia
  • Tiredness
  • Sore tongue

How is methyl malonic acid quantitative test performed?

A blood sample is drawn from the arm for this test and a needle is used to draw the blood.

What are the parameters measured in methyl malonic acid quantitative test?

Methyl malonic acid quantitative test increases the amount of MMA in the blood which is an indicator of vitamin B12 deficiency.

Preparation before performing methyl malonic acid quantitative test

You’ll be asked to fast before sample collection. Also, you should inform your healthcare provider about the medications or supplements you are taking.

Post-care after methyl malonic acid quantitative test

You may resume your normal routine after the methyl malonic acid quantitative test.

Sample types in methyl malonic acid quantitative test

A blood sample is taken from the vein in your arm. In newborns, the blood sample is taken from the heel stick. 

Side effects/risks of methyl malonic acid quantitative test

A needle is used to draw blood in the methyl malonic acid quantitative test and it carries risks such as:

  • Bleeding or infection at the needle site
  • Slight pain
  • Bruising may occur

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