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What is CD117?

CD117, or KIT protein, is a protein which triggers cell division and differentiation.

What is CD117 test? 

CD117 test is a test performed to diagnose gastrointestinal stromal tumors (GISTS).1

 Why is CD117 test suggested? 

Symptoms for GIST include:

  • Pain or discomfort in the abdomen.
  • Bowel obstruction.
  • Nausea and vomiting.
  • A mass in the abdomen which can be felt by hand.
  • Vomiting of blood.
  • Blood in the stool.
  • Fatigue due to anemia.

You must go and see a doctor if these symptoms persist.

How is CD117 test performed? 

Before the tests, the doctor performs a physical examination and also asks questions about your appetite, medical history, current medical problems and treatments, weakness, pain, weight loss, etc.

Certain imaging tests like MRI and CT scan are done to look for a tumor. One of the following criteria is performed to confirm whether the tumor is cancerous:

  • Biopsy by removing a small number of tissues from the tumor site. Anaesthesia is given before the needle is inserted and depending on the part of the body, you may have to lie on your stomach or your back or sit up.
  • Tumour pathology in which the doctor looks at the shape and appearance of the tumor cells by doing tests for a protein called KIT to diagnose GIST.

Additional laboratory tests might be conducted on the tumor sample.

What are the parameters measured in CD117 test? 

If the test result is positive for the presence of KIT protein, it indicates the presence of a gastrointestinal stromal tumor.

If the doctor suspects that the tumor is cancerous, but the CD117 test result is weak or negative, then additional tests may be done to identify the tumor.

 

Preparation before performing CD117 test

Preparation for a biopsy depends on the type of test you are going to have. The doctor will ask you certain questions before the tests. Inform your doctor if you are on any medication and have a medical condition. The doctor will give you instructions depending on your condition. Ask your doctor if you can eat or drink before the test.   

Post-care after CD117 test 7

Wear the bandage placed by the doctor at the needle site for 24 hours in case of biopsy. In the case of a blood test, place the bandage for 30 mins-1 hour. Avoid any strenuous activity throughout the day.

Sample types in CD117 test 2

Samples collected are tissues or cells.

Side effects/risks of CD117 test 5

Biopsy and blood tests are very safe procedures. Complications are extremely rare which include bleeding, pain, fever or discomfort. Tell your doctor if you are facing these problems.

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