BRAF V600E Mutations

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Overview Brief

The BRAF V600E gene mutation test is commonly used for detecting multiple cancer types like melanoma and colorectal cancer.

What Is BRAF V600E Mutation Test?

BRAF V600E gene mutation test is the most common mutation tested in clinical laboratories for cancer.

BRAF is a serine/threonine protein kinase activating the MAP kinase/ERK-signaling pathway. If the V600E mutation is found in the BRAF gene then it is a positive result for the gene mutation test. This test has emerged as an important tool for diagnosis, prognosis, treatment, and predicting patient outcome in response to targeted therapy for multiple cancer types.

The BRAF V600E mutation is a powerful molecular marker for papillary thyroid carcinoma and, hairy cell leukemia as well.

Why Is BRAF V600E Mutation Test Suggested?

BRAF V600E gene mutation test is used because:

  • It is a highly sensitive and specific methodology.
  • Ideal for precision targeting cancer therapy.
  • It helps effectively plan cancer treatment.

How Is BRAF V600E Mutation Test Performed?

The V600E mutation test is performed by:

  • Taking relevant blood or tissue sample.
  • The tissue is prepared with formalin-fixed, paraffin embedded base.
  • Polymerase Chain Reaction(PCR) amplification of target DNA is done.
  • Target DNA is detected by automated real-time PCR.

Cross-reactivity is possible with other related non-V600E mutants.

What Are The Parameters Measured In BRAF V600E Mutation Test?

Mutation of V600E is confirmed in the BRAF gene sequence.      

Preparation Before Performing BRAF V600E Mutation Test

No special preparation is required before the BRAF gene mutation test.

Post-Care After BRAF V600E Mutation Test

No special post-care is required after the BRAF gene mutation test.

Sample Types In BRAF V600E Mutation Test

Only blood or specific tissue samples are required to find BRAF gene mutation.


Side Effects/Risks Of BRAF V600E Mutation Test

There are no risks associated with the BRAF gene mutation test.


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