Beta Catenin

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Overview Brief

If your physician suspects the presence of cancers in the ovary, breast or liver, a Beta-Catenin test will help confirm their existence in your body.

What is Beta-Catenin?

Beta-Catenin is a diagnostic test used to detect any mutations in the Beta-Catenin gene and thus detect certain diseases like ovarian cancer.

The Beta-Catenin protein helps in the differentiation of cells as well as in cell-to-cell adhesion. Mutations of this protein show up as nuclear/cytoplasmic staining in the Beta-Catenin test, as opposed to membrane staining in normal cases.

Mutations as indicated in the Beta-Catenin test typically imply the presence of diseases like ovarian/liver cancer, osteosarcoma or liposarcoma.

Why is Beta-Catenin suggested?

The Beta-Catenin test is usually suggested for the following reasons.

  • To confirm the presence of tumors in the liver, lungs, ovaries or pancreas.
  • To confirm non-cancer illnesses like Gardner Syndrome [1].

How is Beta-Catenin performed?

Beta-Catenin test is carried out by a designated pathologist.

  • Tissue samples are collected through biopsy or other procedures.
  • The samples are studied on slides after being embedded in paraffin wax [2].
  • Tissue immunohistochemistry is used to assess mutations in the Beta-Catenin protein.

The Beta-Catenin samples must be transported in an ice pack.

What are the parameters measured in Beta-Catenin?

The following parameters are typically measured in the Beta-Catenin test.

  • The percentage of positively stained cells.
  • The level of stained proteins in the nucleus and/or cytoplasm.

Preparations before performing Beta-Catenin

The following preparations are advised before performing the Beta-Catenin test.

  • Informing physicians of all medications being taken and prior medical history.

Post-care after Beta-Catenin

No special post-care is needed after the Beta-Catenin test.

Sample types with Beta-Catenin

The following sample types are required in the Beta-Catenin test.

  • One block of paraffin waxed tissue.

Side effects/risks of Beta-Catenin

Beta-Catenin test typically involves the following potential risks.

  • Distortion of results due to existing medications.

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