If your physician suspects the presence of cancers in the ovary, breast or liver, a Beta-Catenin test will help confirm their existence in your body.
What is Beta-Catenin?
Beta-Catenin is a diagnostic test used to detect any mutations in the Beta-Catenin gene and thus detect certain diseases like ovarian cancer.
The Beta-Catenin protein helps in the differentiation of cells as well as in cell-to-cell adhesion. Mutations of this protein show up as nuclear/cytoplasmic staining in the Beta-Catenin test, as opposed to membrane staining in normal cases.
Mutations as indicated in the Beta-Catenin test typically imply the presence of diseases like ovarian/liver cancer, osteosarcoma or liposarcoma.
Why is Beta-Catenin suggested?
The Beta-Catenin test is usually suggested for the following reasons.
- To confirm the presence of tumors in the liver, lungs, ovaries or pancreas.
- To confirm non-cancer illnesses like Gardner Syndrome .
How is Beta-Catenin performed?
Beta-Catenin test is carried out by a designated pathologist.
- Tissue samples are collected through biopsy or other procedures.
- The samples are studied on slides after being embedded in paraffin wax .
- Tissue immunohistochemistry is used to assess mutations in the Beta-Catenin protein.
The Beta-Catenin samples must be transported in an ice pack.
What are the parameters measured in Beta-Catenin?
The following parameters are typically measured in the Beta-Catenin test.
- The percentage of positively stained cells.
- The level of stained proteins in the nucleus and/or cytoplasm.
Preparations before performing Beta-Catenin
The following preparations are advised before performing the Beta-Catenin test.
- Informing physicians of all medications being taken and prior medical history.
Post-care after Beta-Catenin
No special post-care is needed after the Beta-Catenin test.
Sample types with Beta-Catenin
The following sample types are required in the Beta-Catenin test.
- One block of paraffin waxed tissue.
Side effects/risks of Beta-Catenin
Beta-Catenin test typically involves the following potential risks.
- Distortion of results due to existing medications.