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Apolipoprotein E

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The Apolipoprotein E blood genotyping is a rare type of blood test that is used to help diagnose Alzheimer disease in adults. 

What is Apolipoprotein E?

The apolipoprotein E (APOE) genotype is a genetic risk factor for developing dementia, Alzheimer disease, and cardiovascular disease. It is among the more common genotypes. Apolipoprotein E test is used as an aid to diagnose the probable late onset of Alzheimer disease in an adult showing symptoms.2

Why is Apolipoprotein E suggested?

An Apolipoprotein E test is ordered by the doctor if the patient has the following signs and symptoms:1

  • Progressive symptoms of dementia.
  • High cholesterol.
  • High triglyceride levels.
  • Xanthomas, which are raised yellowish patches on the skin.

How is Apolipoprotein E performed?

The Apolipoprotein E test is done in the following way:2

  • A small sample of blood is drawn from the patient’s arm.
  • The sample is sent to the laboratory for analysis.

This is how an Apolipoprotein E test is done.

What are the parameters measured in Apolipoprotein E?

The Apolipoprotein E test tests a person’s DNA to determine the combination of APOE forms present. The APOE gene exists in three different forms, e2, e3, and e4. E3 is the most common allele. People inherit two APOE genes, one from each parent, and it is a combination of two of the three forms.

Preparation before performing Apolipoprotein E

There is no special preparation necessary before performing the Apolipoprotein E test but you might want to go for genetic counseling before the test. 1

Post-care after Apolipoprotein E

There is no post-care necessary after Apolipoprotein E test.

Sample types in Apolipoprotein E

The sample type in Apolipoprotein E test is:

  •  Blood

Side effects/risks of Apolipoprotein E

The Apolipoprotein E test has no known side effects or risks apart from:

  • A little pain or bruising at the spot where blood was drawn.

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